Estimate daily vitamin D3 needed to reach a target serum 25(OH)D level.
The Endocrine Society defines deficiency as serum 25(OH)D <20 ng/mL, insufficiency as 21–29 ng/mL, and sufficiency at ≥30 ng/mL. Many integrative clinicians target 40–60 ng/mL for optimal immune and bone health. Levels above 100 ng/mL carry a risk of hypercalcemia.
For documented deficiency, clinicians often use 50,000 IU vitamin D2 or D3 weekly for 8 weeks followed by maintenance dosing.