Calculate PRBC volume to reach target hemoglobin.
Volume (mL) = EBV × (Target Hb − Current Hb) / (PRBC Hct/3). PRBC hematocrit is typically 55–65%. Rule of thumb: 10 mL/kg of PRBC raises hemoglobin by ~2–3 g/dL. Transfuse at 5–10 mL/kg/hr. For neonates, use CMV-negative, irradiated, leukoreduced products. Always reassess after transfusion.